Naproxen Alternatives: Safer Pain Relief Options You Can Try

When naproxen, a nonsteroidal anti-inflammatory drug (NSAID) used for pain, swelling, and fever. Also known as Aleve, it's one of the most common over-the-counter pain relievers stops working—or causes stomach upset, high blood pressure, or kidney concerns—you need options that actually work without the side effects. Many people reach for naproxen because it lasts longer than ibuprofen, but if you’re tired of the burn, the bloating, or the warnings on the label, there are smarter ways to manage pain.

One of the most straightforward swaps is ibuprofen, another NSAID that reduces inflammation and pain but has a shorter duration. It’s gentler on the stomach for some, and you can find it in lower doses daily without the same long-term risks as naproxen. Then there’s acetaminophen, a painkiller that doesn’t reduce inflammation but is much safer for the gut and kidneys. It’s the go-to for people with ulcers, high blood pressure, or kidney disease because it doesn’t interfere with blood flow to the kidneys like NSAIDs do. For chronic joint pain, topical treatments like diclofenac gel can deliver relief right where you need it, without swallowing a pill. And if you’re dealing with arthritis or muscle pain, physical therapy, heat wraps, or even low-dose antidepressants like amitriptyline (yes, they help with nerve pain too) can be surprisingly effective.

Some people turn to natural options like turmeric, ginger, or omega-3s—but don’t assume they’re risk-free. These can interact with blood thinners, diabetes meds, or even affect surgery outcomes. Always check with your doctor before swapping one substance for another, especially if you’re on other meds. The truth is, there’s no one-size-fits-all pain solution. What works for your neighbor might not work for you, and that’s okay. The goal isn’t to find the strongest drug, but the safest one that gets you through your day.

Below, you’ll find real-world comparisons and patient-tested alternatives to naproxen—from common OTC switches to lesser-known options that doctors actually recommend. No fluff. No marketing. Just what works, what doesn’t, and what to watch out for.