Dry Eyes from Medications: What’s Causing It and What You Can Do

When your eyes feel gritty, burning, or constantly dry, it’s easy to blame the weather or too much screen time. But if you’re taking any regular medication, the real culprit might be hiding in your pill bottle. Dry eyes from medications, a common yet often overlooked side effect caused by drugs that reduce tear production or change tear composition. Also known as medication-induced dry eye syndrome, this isn’t just discomfort—it can lead to lasting damage if ignored. It’s not rare. Studies show over 70% of people on long-term prescriptions report some level of eye dryness, and many never connect it to what they’re taking.

Some of the most common offenders are antihistamines, drugs used for allergies that reduce fluid production throughout the body, including tears. If you’re on loratadine, cetirizine, or diphenhydramine, your dry eyes might be a direct result. Beta-blockers, often prescribed for high blood pressure or heart conditions, also cut tear production by slowing down nerve signals to the tear glands. Even antidepressants, especially SSRIs and tricyclics, can dry out your eyes by affecting the autonomic nervous system that controls blinking and tear flow. And don’t forget about acne meds like isotretinoin, birth control pills, or even decongestants—they all chip away at your natural eye moisture.

The problem isn’t always the drug itself—it’s how long you’ve been on it, what else you’re taking, and whether your body has started to adapt. People over 50, women going through menopause, or those with autoimmune conditions like Sjögren’s syndrome are at higher risk. But even young, healthy people can notice symptoms after starting a new medication. The good news? You don’t have to live with it. Simple fixes like switching to preservative-free artificial tears, using a humidifier at night, or adjusting your dosage under your doctor’s guidance can make a big difference. Some medications can be swapped for alternatives that are gentler on your eyes. And if you’re unsure whether your pills are the cause, tracking when symptoms started and matching them to new prescriptions can help you and your doctor spot the link fast.

Below, you’ll find real stories and science-backed insights from people who’ve dealt with this exact issue—how they figured out what was causing their dry eyes, what worked, and what didn’t. Whether you’re on blood pressure meds, antidepressants, or just wondering why your eyes won’t stop feeling like sandpaper, these posts give you the practical details you need to take control.